Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
June 28, 2016
Patent Application Number
14008423
Date Filed
March 29, 2012
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.
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