The present disclosure generally relates to alcohol antimicrobial skin sanitizing compositions for use in hand washing and skin sanitizing. The antimicrobial skin sanitizing composition comprises an alcohol for providing effective antimicrobial control, one or more cationic compounds for moisturizing and protecting the skin, and a compatible thickening system for thickening the antimicrobial skin sanitizing composition. The antimicrobial skin sanitizing compositions can be used alone or in combination with personal care products.