US Patent 9429350 Shipping box system with multiple insulation layers

The present invention relates to a box system for keeping medicine and other payloads at a desired temperature for prolonged periods of time. The system generally includes three or more insulating materials between a refrigerant and the payload so that the payload is not cold-shocked by the refrigerant but instead maintains a desired temperature range during shipment. An advantage of the box system of certain embodiments of the present disclosure is that the system allows a shipper to use a temperature controlled system that is effective in controlling temperature without the need for any expensive phase change materials. A box having foldable tabs for securing the materials to each other is also disclosed herein.