Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
September 20, 2016
Patent Application Number
14388597
Date Filed
March 25, 2013
Patent Citations Received
Patent Primary Examiner
Patent abstract
Disclosed herein are novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. The cationic lipids can demonstrate enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency and tolerability of in vivo delivery of siRNA.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
