Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Carl E. Frasch0
Che-Hung Robert Lee0
Date of Patent
October 25, 2016
0Patent Application Number
149304250
Date Filed
November 2, 2015
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
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