A self-balancing vehicle frame includes two side frame units and a bearing unit interconnecting the side frame units such that each of the side frame units can tilt independently against the other of the side frame units. Each of side frames is mounted with a wheel, a driver, and a self-balancing electric system integrated with a pedal and handle. Through operation of hands and feet, each of the side frame units is operable to tilt the corresponding components forwardly and rearwardly. As such, a user can operate the vehicle using hands and/or feet to control travelling and turning of the vehicle.