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US Patent 9499629 Use of chimeric antigen receptor-modified T-cells to treat cancer

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Is a

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Bruce L. Levine0

David L. Porter0

Michael C. Milone0

Michael D. Kalos0

Carl H. June0

Date of Patent

November 22, 2016

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Patent Application Number

139926220

Date Filed

December 9, 2011

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Patent Citations Received

US Patent 12109234 Anti-BCMA CAR T cell compositions

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US Patent RE49847 Nucleic acid molecules encoding chimeric antigen receptors comprising a CD20 binding domain

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US Patent 11938153 Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling

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US Patent 11939389 BCMA chimeric antigen receptors and uses thereof

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US Patent 11952428 BCMA chimeric antigen receptors and uses thereof

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US Patent 12006369 BCMA chimeric antigen receptors

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US Patent 12024719 Transgenic macrophages, chimeric antigen receptors, and associated methods

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US Patent 12076378 Use of car and bite technology coupled with an SCFV from an antibody against human thymidine kinase 1 to specifically target tumors

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Patent Primary Examiner

Michael Burkhart

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Patent abstract

The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.

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