Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
David M. Valenzuela0
Ka-Man Venus Lai0
Wojtek Auerbach0
David Frendewey0
George D. Yancopoulos0
Date of Patent
January 17, 2017
Patent Application Number
14515503
Date Filed
October 15, 2014
Patent Citations Received
0
Patent Primary Examiner
Patent abstract
Compositions and methods are provided for modifying a genomic locus of interest in a eukaryotic cell, a mammalian cell, a human cell or a non-human mammalian cell using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Further methods combine the use of the LTVEC with a CRISPR/Cas system. Compositions and methods for generating a genetically modified non-human animal comprising one or more targeted genetic modifications in their germline are also provided.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.