Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Joseph Nti-Gyabaah0
Christine Cho Lee0
Matthew Pettroff0
Ijeoma Ikechukwu0
Date of Patent
January 31, 2017
Patent Application Number
14131280
Date Filed
July 3, 2012
Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention relates generally to methods for purifying a Fc-fusion protein produced in a eukaryotic expression system. More specifically, the invention provides a robust and scalable downstream purification process suitable for use in manufacturing TNFR:Fc for human administration which comprises an optimized Protein A affinity chromatography step and two ion exchange chromatography steps both of which are operated in the bind-and-elute mode.
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