Patent 9567573 was granted and assigned to Sangamo Biosciences Inc. on February, 2017 by the United States Patent and Trademark Office.
Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a DNA binding domain and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.