Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Violetta Akopian0
David Webb0
Priya Karmali0
Richard P. Witte0
Robin Lee0
Victor Knopov0
Date of Patent
February 28, 2017
0Patent Application Number
136690780
Date Filed
November 5, 2012
0Patent Citations Received
Patent Primary Examiner
Patent abstract
What is described is a method for preparing a liposome that efficiently encapsulates a negatively charged therapeutic polymer, e.g., siRNA. The process involves preparing a lipid mixture comprising a cationic lipid in a water miscible organic solvent, such as ethanol, at a concentration of 2.3 mg/ml, and adding this solution to the polymer dissolved in water to a final concentration of 35% ethanol in water. The final charge ratio of drug:lipid is 1:2.5. The resulting nanoparticles have a mean size of 50 to 150 nm.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.