Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Qun Zhou0
Robert Miller0
Bo Chen0
Clark Pan0
Diego Gianolio0
Huawei Qiu0
James Stefano0
Pradeep Dhal0
Date of Patent
February 28, 2017
0Patent Application Number
142034790
Date Filed
March 10, 2014
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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