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US Patent 9615550 Genetically modified major histocompatibility complex mice

Patent 9615550 was granted and assigned to Regeneron Pharmaceuticals on April, 2017 by the United States Patent and Trademark Office.

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Patent abstract

The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

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