The present disclosure provides tobacco-derived pyrolysis oils and derivatives thereof, such as isolated components and mixtures obtained from such pyrolysis oils. Advantageously, the tobacco-derived pyrolysis oils disclosed herein can exhibit desirable sensory characteristics. Further, tobacco-derived pyrolysis oils disclosed herein can exhibit desirably low concentrations of benzo[a]pyrene. The disclosure also provides methods for obtaining such tobacco-derived pyrolysis oils and derivatives thereof.