Patent 9676708 was granted and assigned to Johns Hopkins University on June, 2017 by the United States Patent and Trademark Office.
Protected HNO donors designed to undergo non-enzymatic release at neutral pH via an intramolecular cyclization-elimination are disclosed. The rate of cyclization, and therefore HNO release, can be controlled by substituents and chain length. Thus, biologically useful HNO donors having tunable HNO release rates are provided.