Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Galina Obmolova0
Raymond Sweet0
Tatiana Ort0
Thomas Malia0
Alexey Teplyakov0
Damon Hamel0
Johan Fransson0
John Chen0
...
Date of Patent
June 20, 2017
Patent Application Number
14790144
Date Filed
July 2, 2015
Patent Citations Received
Patent Primary Examiner
Patent abstract
Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
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