Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Kenjirou Minomi0
Wenbin Ying0
Cima Cina0
Hirokazu Takahashi0
Jens Harborth0
Kwok Yin Tsang0
Date of Patent
July 4, 2017
0Patent Application Number
149795710
Date Filed
December 28, 2015
0Patent Citations Received
Patent Primary Examiner
Patent abstract
This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2′-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.
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