Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Phillip B. Maples0
Donald Rao0
John J. Nemunaitis0
Neil Senzer0
Date of Patent
July 4, 2017
0Patent Application Number
148449120
Date Filed
September 3, 2015
0Patent Primary Examiner
Patent abstract
Compositions and methods to attenuate the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs is described herein. The bi-functional shRNAs of the present invention knocks down the expression of furin in cancer cells to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.
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