A syringe assembly including: (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap assembly containing a cap and an absorbent material is removably attached to the plunger. An antiseptic cap and syringe combination includes a syringe barrel having an access point connection, and a tip cap having a proximate chamber and a distal chamber. The proximate chamber releasably receives and engages the access point connection of the syringe, and the distal chamber removably receives and engages an antiseptic cap.