Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Diego Gianolio2
Pradeep Dhal2
Bo Chen2
Clark Pan2
Huawei Qiu2
Date of Patent
July 11, 2017
Patent Application Number
14203438
Date Filed
March 10, 2014
Patent Citations Received
Patent Primary Examiner
Patent abstract
Provided are binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof, comprising a CH1 domain (e.g., a human IgG1 CH1 domain), wherein the CH1 domain has an engineered N-linked glycosylation site at amino acid position 114, according to Kabat numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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