Patent 9708386 was granted and assigned to Regeneron Pharmaceuticals on July, 2017 by the United States Patent and Trademark Office.
The present invention provides VEGF antagonists with improved pharmacokinetic properties. According to certain embodiments, a fusion polypeptide capable of antagonizing VEGF activity is provided comprising a modified extracellular ligand binding domain of a VEGF receptor fused to a multimerizing component.