A door opening and closing device includes: a resin-made base attached to an inner panel of a door; and a transfer mechanism provided on an interior side of the base, and transferring power to a locking device via a power transfer cable, wherein the base includes first and second parts in which the transfer mechanism and the cable are disposed respectively, and a fixing portion fixing an outer casing end portion of the cable, and wherein the first and second parts are configured to locate at different levels so that the second part is positioned closer to an inner side than the first part in a width direction, a step portion is provided between the first and second parts, and the fixing portion is provided in the step portion.