US Patent 9783790 Trichoplusia ni piggybac transposases with reduced integration activity
Patent 9783790 was granted and assigned to Johns Hopkins University on October, 2017 by the United States Patent and Trademark Office.
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Patent abstract
The present invention is directed to nucleic acid and amino acid sequences of a novel piggyBac transposase enzymes created by modifying the transposase of Trichoplusia ni. The piggyBac transposases of the present invention are functionally active or hyperactive for excision and have decreased integration activity compared to wild type Trichoplusia ni piggyBac transposase enzyme. These transposases are ideal for use in methods of transforming cells and organisms. In particular embodiments, the present invention provides methods of transient integration and expression of transgenes.
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US Patent 09783790 Trichoplusia ni piggybac transposases with reduced integration activity US Patent 9783790 Trichoplusia ni piggybac transposases with reduced integration activity
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Patent Number
0978379000
Patent Number
978379000
Edits on 27 Apr, 2023
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Is a
Current Assignee
Patent Jurisdiction
Patent Number
097837900
Date of Patent
October 10, 2017
0Patent Application Number
142330240
Date Filed
July 16, 2012
0Patent Primary Examiner
Edits on 25 Sep, 2022
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Infobox
Is a
Current Assignee
Patent Jurisdiction
Patent Number
097837900
Date of Patent
October 10, 2017
0Patent Application Number
142330240
Date Filed
July 16, 2012
0Patent Primary Examiner
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US Patent 09783790 Trichoplusia ni piggybac transposases with reduced integration activity
Infobox
Is a
Current assignee
Patent jurisdiction
Patent number
09783790
Date of patent
October 10, 2017
Patent application number
14233024
Date Filed
July 16, 2012
Patent primary examiner
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