Patent 9790465 was granted and assigned to Corning on October, 2017 by the United States Patent and Trademark Office.
A spheroid cell culture article including:a frame having a chamber including:an opaque side wall surface;a top aperture;a gas-permeable, transparent bottom; andoptionally a chamber annex surface and second bottom,and at least a portion of the transparent bottom includes at least one concave arcuate surface, is disclosed. Methods of making and using the article are also disclosed.