Systems and methods are disclosed for mitigating interference between Radio Access Technologies (RATs) sharing operating spectrum in an unlicensed band of radio frequencies. The mitigation may comprise, for example, identifying an upcoming signal transmission associated with a first RAT, with the signal transmission being scheduled for transmission on the shared operating spectrum during a transmission period. The signal transmission may be classified with respect to a protection status. Based on the protection status, a channel reservation message may be transmitted that is associated with a second RAT to reserve at least a portion of the shared operating spectrum for at least a portion of the transmission period.