Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
November 7, 2017
Patent Application Number
14355010
Date Filed
October 31, 2012
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to novel depot formulations (prodrugs) comprising an immobility promoting unit linked via an ester to an active pharmaceutical ingredient, i.a. common NSAIDs. The novel depot formulations are suitable for intra-articular injections and are soluble at slightly acidic pH to facilitate ease of injection, and sparingly soluble at physiological pH thereby precipitating at the site of administration. The precipitate will slowly dissolve and the active drug is released from dissolved depot formulation following esterase mediated cleavage of the ester link between the immobility promoting unit and the active pharmaceutical agent.
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