A lockable, reusable plug for hermetically-sealing an opening, such as an alcoholic beverage bottle consists of a threaded wing bolt with an opening therethrough and a threaded stem; a domed, shouldered cap having an axial bore, an elastomeric sealing gasket having an opening, and a base nut having a threaded axial bore for mating with the threaded stem. Positioning the gasket between the compression cap and compression base nut, the bolt is inserted through the assembly, making the plug ready for insertion into an opening to be sealed. A flange on the gasket and the cap support the plug on the rim of the opening to be sealed. Screwing the bolt further into the assembly urges the plates toward one another compressing and causing the gasket to extend radially outward creating the seal. Insert the shackle of padlock through opening of bolt, lock padlock, shoulders prevent removal of plug.