A method is used in deduplicating sets of data blocks. A candidate data object is identified for deduplicating a data object. A digest associated with the candidate data object matches a digest associated with the data object. Digest information of a set of data objects is evaluated. The set of data objects are selected for evaluation based on an association between location of the set of data objects and location of the candidate data object. Based on the evaluation, a deduplicating technique is applied for deduplicating the data object.