Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
January 30, 2018
Patent Application Number
15029599
Date Filed
October 15, 2014
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to triorthogonal reagents useful for site-specifically modifying a protein with two orthogonal groups that can be subsequently functionalized in a single one-pot procedure. This approach relies on the selective tagging of proteins containing an appended farnesyltransferase or geranylgeranyltransferase I substrate sequence. The incorporation of a bifunctional ethynyl-hydroxybenzaldehyde into the farnesyl or geranylgeranyl group facilitates the facile labeling of proteins with two different moieties.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
