Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jordan J. Green0
Stephany Y. Tzeng0
Ron B. Shmueli0
Joel C. Sunshine0
Nupura S. Bhise0
Date of Patent
February 6, 2018
0Patent Application Number
146443970
Date Filed
March 11, 2015
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
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