Is a
Patent attributes
Current Assignee
0
Patent Jurisdiction
Patent Number
Patent Inventor Names
Julie Douthwaite0
Steven Rust0
Ralph Minter0
Cyril Privezentzev0
Jacques Moisan0
Michael Bowen0
Date of Patent
February 6, 2018
0Patent Application Number
143996850
Date Filed
March 11, 2013
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Variants of cytotoxic T-lymphocyte antigen 4 (CTLA-4) with high affinity, potency and stability. Formulations of CTLA-4 variants at high concentration for subcutaneous or intravenous administration, e.g. at monthly or less frequent dosage intervals. Use of CTLA-4 variants for treating rheumatoid arthritis and other inflammatory disorders. Fusion of CTLA-4 with IgG Fc having improved stability and longer in vivo half-life.
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