Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Joshua T. Pearson0
Gunasekaran Kannan0
Li Li0
Marc A. Gavin0
Margaret Karow0
Date of Patent
April 3, 2018
0Patent Application Number
154082810
Date Filed
January 17, 2017
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.
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