Patent 9938641 was granted and assigned to Fluidigm Corporation on April, 2018 by the United States Patent and Trademark Office.
Disclosed are methods for performing aptamer preselection based on unique geometry and the content of stems or loops of the aptamer, which methods are capable of providing suitable binders and also permit selection of aptamers performed essentially entirely on a chip or other device. Also disclosed are kits for aptamer selection.