Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
April 24, 2018
Patent Application Number
13750753
Date Filed
January 25, 2013
Patent Citations Received
Patent Primary Examiner
Patent abstract
Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
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