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US Patent 9957227 Pharmaceutical formulations of HDAC inhibitors

Patent 9957227 was granted and assigned to Topotarget UK Limited on May, 2018 by the United States Patent and Trademark Office.

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Patent
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Patent attributes

Patent Applicant
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Topotarget UK Limited
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Current Assignee
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Topotarget UK Limited
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
99572270
Patent Inventor Names
Richard J. Bastin0
Nicholas J. Hughes0
Date of Patent
May 1, 2018
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Patent Application Number
158135820
Date Filed
November 15, 2017
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Patent Primary Examiner
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Karl J Puttlitz
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Patent abstract

This invention pertains to pharmaceutical compositions comprising certain carbamic acid compounds (e.g., which inhibit HDAC (histone deacetylase) activity) (e.g., PXD-101, N hydroxyl-3-(3-phenylsulfamoyl-phenyl)-acrylamide)) and one or more additional ingredients selected from cyclodextrin, arginine, and meglumine. The present invention also pertains to the use of such compositions, for example, in the inhibition of HDAC, and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.

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