Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Andrew D. Cohen0
Lisa Marie Frost0
Stephen Martin Courtney0
Vincent Jacob Kalish0
Frederick Arthur Brookfield0
John P. Toscano0
Date of Patent
May 15, 2018
0Patent Application Number
156403420
Date Filed
June 30, 2017
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
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