Methods of maximizing mixing and melting in a submerged combustion melter (SCM) are described. One method includes melting an inorganic feedstock in an SCM using an arrangement of two or more submerged combustion (SC) burners, the SCM having a length (L) and a width (W), a centerline (C), a north side (N) and a south side (S), and operating the arrangement of SC burners such that a progressively higher percentage of a total combustion flow from the SC burners occurs from SC burners at progressively downstream positions in the SCM. Other methods include operating the N and S SC burners with more combustion flow than the central burners. Other methods include strategic placement of fuel lean SC burners and fuel rich SC burners.