Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Woo Jin Park0
Jae Gyun Oh0
Date of Patent
July 13, 2021
0Patent Application Number
166625180
Date Filed
October 24, 2019
0Patent Primary Examiner
Patent abstract
The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X1-Ala-X2—X3-Ile-Glu-X4 (I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB.
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