iBioSim, developed by Chris Myer's research group at University of Utah, primarily targets genetic circuit models but also works with models of metabolic networks, cell-signaling pathways and other biological and chemical systems. Modeling and visualization support for multi-cellular and spatial models is another feature of iBioSim. iBioSim was described in 2009 in Bioinformatics and Version 3 of iBioSim is described in ASC Synthetic Biology in 2018.