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Bardugo was born in Jerusalem, Israel, and grew up in Los Angeles, California, U.S. where she was raised by her grandparents. She is secular Jewish and of Sephardic Jewish (Moroccan-Jewish) descent on her father's side, and of Ashkenazi Jewish (Russian-Jewish and Lithuanian-Jewish) descent on her mother's side.
She attended Yale University, graduating with a degree in English in the spring of 1997. She was a member of the Wolf's Head secret society. Before publishing her first novel, she worked in copywriting and journalism, as well as makeup and special effects.
Bardugo's debut novel, Shadow and Bone, the first book in the Grisha trilogy, was published in 2012 by Macmillan. Shadow and Bone was nominated for the Romantic Times Book Award and the South Carolina Children's Book Award, named an Indie Next List Book, and reviewed in The New York Times. The novel hit #8 on The New York Times Best Seller list, and had been optioned for film by David Heyman and DreamWorks. The other books in the trilogy, Siege and Storm and Ruin and Rising, were published by Macmillan in 2013 and 2014 respectively. Bardugo defines Shadow and Bone genre as Tsarpunk - a fantasy with inspiration from early 19th century Russia.
The Six of Crows duology (Six of Crows and Crooked Kingdom) was published by Macmillan in 2015 and 2016. It is set in the same universe as the Grisha trilogy (sometimes collectively referred to as the "Grishaverse"). Six of Crows was named a New York Times Notable Book and an ALA-YALSA Top Ten Pick of 2016. The Language of Thorns, a collection of Grisha fairy tales and folk tales, was published by Macmillan in 2017.
Bardugo then wrote the first book in the DC Icons series, which are novelizations of DC Comics' biggest superheroes; her Wonder Woman: Warbringer was published by Penguin Random House in 2017.
In 2019, Bardugo published her first adult novel, Ninth House, which won the 2019 Goodreads Choice Award for best fantasy novel.
Bardugo also has essays and short stories in anthology collections such as Last Night, A Superhero Saved My Life, Slasher Girls and Monster Boys, and Summer Days and Summer Nights. Her books have been translated into 22 languages and published in over 50 countries.
Bardugo appeared on a Grishaverse panel alongside showrunner Heisserer at New York Comic Con in October 2020. She was ranked the sixth most popular author between 2016 and 2021 on Goodreads.
Main article: Shadow and Bone (TV series)
In September 2012, DreamWorks acquired the movie rights to Shadow and Bone with David Heyman and Jeffrey Clifford producing, although this project was not realized. In January 2019, Netflix ordered an eight-episode series based on the Shadow and Bone and Six of Crows book series.
In October 2019, Amazon Studios announced that it would adapt Ninth House. Bardugo is set to executive produce the project alongside Pouya Shahbazian.
In the acknowledgements section of Six of Crows, Bardugo reveals she suffers from osteonecrosis and sometimes needs to use a cane; this was a source of inspiration for one of the story's six protagonists, master thief and gang boss Kaz Brekker, who uses a cane.
Bardugo was a singer in the band Captain Automatic from 2006 to 2007.
Bardugo eloped with her partner of 4 years in January 2022.