Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
November 6, 2018
Patent Application Number
15655317
Date Filed
July 20, 2017
Patent Citations Received
0
Patent Primary Examiner
Patent abstract
Disclosed are prodrugs of anthracyclines (such as doxorubicin) and derivatives thereof that are selectively cleaved and activated by fibroblast activating protein (FAP). The prodrugs are useful for targeted delivery of “warhead” anthracycline or anthracycline derivative to FAP-expressing tissues, including cancer (e.g., solid tumors). Also provided are pharmaceutical compositions comprising the prodrugs, as well as methods of using the prodrugs to treat a disorder characterized by FAP upregulation, e.g., cancer, undesirable fibrosis, and undesirable inflammation.
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