Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Sarah E. Poplawski0
Wengen Wu0
David G. Sanford0
Hung-sen Lai0
William W. Bachovchin0
Date of Patent
October 22, 2024
0Patent Application Number
172206350
Date Filed
April 1, 2021
0Patent Citations
...
Patent Primary Examiner
Patent abstract
Disclosed are prodrugs of cytotoxic anthracyclines (such as doxorubicin) and other therapeutic agents that are selectively cleaved and activated by fibroblast activating protein (FAP). The prodrugs are useful for targeted delivery of cytotoxic and other agents to FAP-expressing tissues, including cancer (e.g., solid tumors). Also provided are pharmaceutical compounds comprising the prodrugs, as well as methods of using the prodrugs to treat a disorder characterized by FAP upregulation, e.g., cancer, fibrosis, and inflammation.
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