Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
David G. Sanford0
Hung-sen Lai0
Sarah E. Poplawski0
Wengen Wu0
William W. Bachovchin0
Date of Patent
April 2, 2019
Patent Application Number
15318627
Date Filed
June 15, 2015
Patent Citations Received
0
Patent Primary Examiner
Patent abstract
Disclosed are prodrugs of therapeutic or imaging agents, which prodrugs are selectively cleaved by fibroblast activating protein (FAP) to release the agents. Upon cleavage by FAP of the FAP substrate, the prodrug releases the agent in its active form or in a form that is readily metabolized to its active form. Pharmaceutical compositions comprising the prodrugs, as well as methods of using the prodrugs to treat a disorder characterized by FAP upregulation are also disclosed.
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