Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Kallanthottathil G. Rajeev0
Ivan Zlatev0
Muthiah Manoharan0
Shigeo Matsuda0
Date of Patent
November 6, 2018
0Patent Application Number
151106580
Date Filed
January 9, 2015
0Patent Citations Received
Patent Primary Examiner
Patent abstract
One aspect of the present invention relates to double-stranded RNAi (dsRNA) duplex agent capable of inhibiting the expression of a target gene in vivo. The dsRNA duplex comprises one or more 4′-modifications in one or both strand. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for in vivo therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g., for the treatment of various disease conditions.
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