US Patent 10161937 Systems, methods, and workflows for optogenetics analysis
Patent 10161937 was granted and assigned to President and Fellows of Harvard College on December, 2018 by the United States Patent and Trademark Office.
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The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology.
US Patent 10161937 Systems, methods, and workflows for optogenetics analysis
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