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US Patent 10239807 Fused cyclooctyne compounds and their use in metal-free click reactions

Patent 10239807 was granted and assigned to SynAffix B.V. on March, 2019 by the United States Patent and Trademark Office.

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Patent abstract

The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.

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