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Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Byung-Hoon Lee0
Daniel J. Finley0
Min Jae Lee0
Randall W. King0
Timothy C. Gahman0
Date of Patent
July 16, 2019
0Patent Application Number
149336710
Date Filed
November 5, 2015
0Patent Citations Received
0
Patent Primary Examiner
Patent abstract
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.
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