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US Patent 11459335 N/O-linked Degrons and Degronimers for protein degradation

Patent 11459335 was granted and assigned to C4 Therapeutics on October, 2022 by the United States Patent and Trademark Office.

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This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.

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