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US Patent 10390522 Non-human animals having a humanized programmed cell death 1 gene

Patent 10390522 was granted and assigned to Regeneron Pharmaceuticals on August, 2019 by the United States Patent and Trademark Office.

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Patent abstract

Non-human animals, and methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanization of a Programmed cell death 1 (Pdcd1) gene. The non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous Pdcd1 gene so that the non-human animals express a PD-1 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).

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