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US Patent 10464989 Polypeptides, cells, and methods involving engineered CD16

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Is a
Patent
Patent

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
10464989
Date of Patent
November 5, 2019
Patent Application Number
15300024
Date Filed
March 27, 2015
Patent Citations Received
‌
US Patent 11883432 Chimeric antigen receptor system with adaptable receptor specificity
0
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US Patent 11352607 Genomic engineering of pluripotent cells
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US Patent 11365394 Enhanced immune effector cells and use thereof
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US Patent 11370825 Polypeptides, cells, and methods involving engineered CD16
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US Patent 10858628 Methods and compositions for inducing hematopoietic cell differentiation
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US Patent 10947505 Methods and compositions for inducing hematopoietic cell differentiation
‌
US Patent 11072781 Genomic engineering of pluripotent cells
‌
US Patent 11634688 Methods and compositions for inducing hematopoietic cell differentiation
0
...
Patent Primary Examiner
Quang Nguyen
Quang Nguyen
Patent abstract

This disclosure describes, generally, a modified form of CD 16, genetically-modified cells that express the modified CD 16, and methods that involve the genetically-modified cells. The modified form of CD 16 can exhibit increased anti-tumor and/or anti- viral activity due, at least in part, to reduced susceptibility to ADAM17-mediated shedding upon NK cell stimulation.

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